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Hyaluronic acid oligosaccharide

Hyaluronic Acid-Oligosaccharide
(HA-Oligo)

Definition

Oligomeric HA, also called hyaluronan oligosaccharide or hyaluronan-oligo, is a kind of small molecule hyaluronic acid with very low degree of polymerization and molecular weight of less than 10,000 Da, that is, less than 50 monosaccharides, or the degree of polymerization less than 25.

INCI Name

:

Hyaluronic Acid

Synonyms

:

Hyaluronan Oligo; HA-oligo; O-HA; Oligomeric HA

CAS No.

:

9004-61-9

EINESC/ELINCS No.

:

232-678-0

Molecular Formula

:

(C14H21NO11)n  ( n<25)

Molecular Weight

:

<10,000Da

Structure:

 

 

Hyaluronic Acid Oligosaccharide ( n<25)

Specifications

Appearance

:

White or almost white powder or granules

Glucuronic acid, %

:

≥44.0%

Hyaluronic acid,%

:

≥91.0%´╝łGlucuronic acid content×2.0675´╝ë

Transparency

:

≥99.0%

 

pH

:

3.0-5.0  (acid form)

 

Loss on drying

:

≤10.0%

 

Protein

:

≤0.1%

 

MICROBIAL TEST

 

 

 

Bacteria Counts

:

<10CFU/g

 

Mold &Yeast

:

<10CFU/g

 

Pseudomonas aeruginosa

:

Negative

 

Staphylococcus aureus

:

Negative

 

 

 

 

 

Packaging and Storage

 

 

 

Packaging

:

100g in bottle, 1kg aluminum foil bag lined a PE bag

Storage

:

Dark, , cool, dry place

Shelf Life

:

2 years at 25°C; 5 years at 4°C

     

Our Advantages

1.      Use a proprietary process so that monosaccharides in the structure of hyaluronic acid will not break down.

2.      Measure the molecular weight of HA-oligo accurately using SEC-MALLS (size exclusion chromatography coupled with multi-angle laser light scatting)

Characteristics

1.      Rapid penetration into skin

 

The penetration rate of HA-oligo is about 3 times that of low molecular weight of hyaluronic acid ( 0.01~0.5×106 Da)

2.      Maintain skin moisture to a deeper layer

 

Hyaluronic acid oligosaccharide rapidly penetrates into corneum to maintain skin’s moisture in a deep layer.

3.      Increase hyaluronic acid content in skin

Since it can penetrate into skin, it will raise HA content in skin, activate skin, anti-aging and comprehensive moisturing.

4.      Good tolerance to heat as compared to medium and high molecular weight of hyaluronic acid.

5.      Easily disperse and dissolve in water with low viscosity.

Use Level

0.05%-0.6% in cosmetics

Documentation:
Formulation



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