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Betamethasone Valerate

Chemical Name /Synonyms

:

Betamethasone 17-valerate; 1,4-Pregnadiene-11b,17a,21-triol-9a-fluoro-16b-methyl-3,20-dione 17-valerate; 9-Fluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17-valerate

CAS No.

:

2152-44-5

EINECS

 

218-439-3

Molecular Formula

:

C27H37FO6

Molecular Weight

:

476.58

Structure

:

 

 

 

Pharmacological Action

A synthetic adrenocorticosteroid for dermatologic use. Betamethasone, an analog of prednisolone, has a high degree of glucocorticoid activity and a slight degree of mineralocorticoid activity. It has anti-inflammatory, anti-pruritic and vasoconstrictive actions.

Use Levels:  0.12% ( equivalent to 0.1% betamethasone)

Suggested Dosage Forms

 

Forms

 

Excipient vehicle

 

Cream

:

Purified water, mineral oil, white petrolatum, polyethylene glycol 1000 monocetyl ether, cetostearyl alcohol, monobasic sodium

phosphate and phosphoric acid or sodium hydroxide, chlorocresol ( preservative)

 

Ointment

:

White petrolatum and mineral oil

 

Lotion

:

Isopropyl alcohol, water, carbomer 934P ( thicker), phosphoric acid or sodium hydroxide (adjust pH)



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