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Sodium hyaluronate

Sodium Hyaluronate
(Hyaluronic Acid, Sodium Salt)

INCI Name

:

Sodium Hyaluronate

Synonyms

:

Hyaluronic acid, sodium salt; Hyaluronan; Hyaluronate; HA for short name

INN Name

 

Hyaluronate Sodium [USAN;JAN]

CAS No.

:

9067-32-7 ( sodium hyaluronate);
9004-61-9 ( hyaluronic acid);

31799-91-4 ( potassium hyaluronate)

EINESC/ELINCS No.

:

232-678-0 ( hyaluronic acid)

Molecular Formula

:

(C14H21NO11)n

Structure:

 

Hyaluronic Acid

Specifications

Test

 

Cosmetic grade

 

Food Grade

Appearance

:

White powder or granules

Glucuronic acid, %

:

≥44.0%

Hyaluronic acid,%

:

≥91.0%(Glucuronic acid content×2.0675)

Transparency

:

≥99.0%

Intrinsic viscosity
& Kinematic Viscosity

:

Practical measured value

pH

:

6.0 -7.5 (MW 0.01-2.0×106Da);

3.0-5.0 ( M.W.<0.01×106Da)

 

6.0~8.0

Loss on drying

:

≤10.0%

 

≤8.0%

Particle size

:

 

 

100% pass through
60 mesh sieve

Heavy metals

:

≤20ppm

Arsenic

:

 

 

≤2ppm

Ash

:

 

 

≤13.0%

Bulk Density

:

 

 

0.20~0.40g/cm3

Protein

:

≤0.05% (MW 0.01-2.0×106Da);

≤0.1% ( M.W.<0.01×106Da)

 

 

Molecular weight range
 (×106Da)

:

(1):  < 0.01

(2):  0.01-0.1

 

0.8-1.5

(3):  0.1-0.5

(4):  0.5-1.0

 

(5):  1.0-1.5

(6):  1.5-2.0

 

 

MICROBIAL TEST

 

 

 

 

Bacteria Counts

:

<10CFU/g

 

≤100CFU/g

Mold &Yeast

:

<10CFU/g

 

≤100CFU/g

E. Coli

:

 

 

Negative

Pseudomonas aeruginosa

:

Negative

 

 

Staphylococcus aureus

:

Negative

 

Negative

Salmonella species

:

 

 

Negative

 

 

 

 

 

Packaging and Storage

 

 

 

 

Packaging

:

100g in bottle, 1kg aluminum foil bag lined a PE bag

Storage

:

Dark, , cool, dry place

Shelf Life

:

2 years at 25°C; 5 years at 4°C

Functions

Hyaluronan is part of the
extracellular matrix, such as:

 

Action

 

A major component
of the synovial fluid

 

• Lubricating

• Tissue hydrodynamics

 

An important component
of articular cartilage

 

• Responsible for the resilience of cartilage

•  Movement and proliferation of cells

 

A major compontent of skin

 

•  Tissue repair, such as sunburn

 

Rich in young brain

 

•  Promote brain development

Application

1.      Medical applications

1.1  Ophthalmic surgery

Corneal transplantation, cataract surgery, glaucoma surgery, and surgery to repair retinal detachment, intra-ocular lens implantation ( IOL implantation )

1.2    Wound repair

Postoperative tissue healing, such as after cataract surgery

Chronic wounds due to diabetes

Repair injured eyes

1.3  Lubricating

Exceptional lubricating properties necessary for skin, heart valves, aqueous/vitreous humor of the eye and synovial fluid ( joint lubricant)

1.4 Osteoarthritis

       Human or equine arthritis

       Ankle and shoulder osteoarthritis pain

1.5 Prevent post-operative adhesions

1.6 Dry, scaly skin (xerosis)

       e.g. atopic dermatitis ( eczema)

2.      Cosmetic applications

2.1 Moisturizing

1)    Water holding capacity

Fig 1 shows that the water holding capacity of sodium hyaluronate is extremely high as compared to other moisturizers

 

       2)    Water retention

Fig 2 shows that the water evaporation rate of sodium hyaluronate is less than that of other moisturizers, which indicate that sodium hyaluronate possesses strong water retention properties.

 

 

       3)   Water uptake ( hygroscopic property)

At low humidity ( RH 33%), sodium hyaluronate has the highest moisture absorbing ability, while at high humidity ( RH 75%), it’s water absorbing property is the lowest.

 

2.2    Lubricating and Film Formation.

Sodium hyaluronate can form a film when applied on the skin. Its low skin slip resistance maintains excellent skin lubricity. It can also form a film on the surface of hair to moisture and lubricate hair and eliminate static electricity of hair, which make hair soft and easy to comb.

 

 

The presence of hyaluronic acid in epithelial tissue has been shown to promote keratinocyte proliferation and increase the presence of retinoic acid, effecting skin hydration. Hyaluronic acid's interaction with CD44 drives collagen synthesis and normal skin function. Present in the extracellular matrix of basal keratinocytes, hyaluronic acid is critical to the structural integrity of the dermal collagen matrix. These benefits make hyaluronic acid a very effective topical humectant, however results may only be sustained as part of an ongoing treatment program.

2.3    Skin repair and rejuvenation

1)      Accelerate the regeneration of injured skin by promoting keratinocyte proliferation, increasing the presence of retinoic acid, effecting skin hydration, driving collagen synthesis.

A good synergetic effect is observed when it is formulated with EGF and heparin

2)      Clear away oxygen free radical. Especially low molecular weight of sodium hyaluronate is extremely helpful for the healing of sunburn, erythema and trauma on the skin,

2.4    Nourishing skin

Low molecular weight sodium hyaluronate and hyaluronic acid oligosaccharide ( HA-Oligo) can reach the corium layer of the skin so as to improve the content of water, nourish skin and expand blood capillary, improve microcirculation and absorption of nutriment.

2.5    Smooth wrinkles

Subcutaneous injection of hyaluronate for filling soft tissue defects such as facial wrinkles. Hyaluronan injections temporarily smooth wrinkles by adding volume under the skin, with effects typically lasting for six months

Use Level            

Typically used at 0.1 - 1%.

Product Forms Available

1.      Sodium Hyaluronate Powder

2.      1% Sodium Hyaluronate

3.      Hyaluronic Acid Oligosaccharide ( HA-Oligo, in the form of acid and sodium salt, respectively)



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