Home  »  Products  »  Cosmetic & Personal Care  »  Skin whitening

3-O-ethyl Ascorbic Acid

DESCRIPTION

3-O-ethyl ascorbic acid is a new generation of Vitamin C derivative that provides superb whitening effects, also serves as a potent anti-aging active that boosts collagen synthesis and protects skin from DNA damage. It exhibits strong inhibition effect on melanogenesis, reduces dark spots and age spots, fights photoaging by interfering with inflammatory cytokines, such as IL-6, and reverse ROS production to achieve free radical scavenging purpose. 3-O-ethyl ascorbic acid is effectively a newer form of Vitamin C that offers a better overall performance. It is water soluble with excellent heat and photostability profile. Best of all, it is highly stable and easy to formulate.

PRODUCT CHARACTERISTICS

Anti-Oxidation

Anti-photoageing (Reduce IL-6)

Inhibit Tyrosinase and Trp-2 Activities (whitening)

Even Out Skin Tone

Stimulate Collagen Synthesis

Reduce Dark Spots (depigmenting)

Protect DNA

Scavenge Free Radicals

Anti-aging

REGULATION

INCI name: 3-O-Ethyl Ascorbic Acid

 

Restrictions:

Japan:

Regulated maxi: 2%(Cosmetic)

South Korea:

Regulated maxi: 2% KFDA No: 2001-15

Taiwan:

Regulated 1-2 %

SPECIFICATIONS / CONDITIONS OF USE

 

Appearance

:

white to off-white crystalline powder

Melting point (°C )

:

111.0-116.0

Water Content

:

≤ 1.0%

pH (3% water solution)

:

4.0-5.5

Heavy metals

:

≤ 20ppm

Arsenic

:

≤ 2ppm

Ash

:

≤0.1%

Assay (HPLC)

:

≥ 98.5%

Free Vc (HPLC)

:

≤10ppm

Total plate count

:

≤500cfu/g

 

DOSAGE

% utilization

0.5 - 2%

 

Formulation Guide

3-O-ethyl ascorbic acid is much stable at a pH range between 5-6.5. It is recommended that dissolve 1g 3-O-ethyl ascorbic acid in 1g citric acid buffer (pH 5.5) and then add to water phase.

*Citric Acid buffer (pH5.5)

%w/w

Citric acid

1.0

Trisodium citrate

15.0

Water

 85.00

 

 

Storage Conditions

Protect from contacting with light, heat and moisture.
Store in tightly closed container at 25°C. It is best to use the entire contents of the pack after opening.

Table 1  Stability and antioxidative of 3-O-ethyl ascorbic acid, ascorbic acid and Magnesium ascorbyl phosphate

Thermal Stability

Antioxidative Activity

[The scavenging activity of 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical]

Retaining rate( 6 weeks at 60°C in aq. solution)

Radical-scavenging activity (IC50 value )

DPPH radical scavenging amount

3-O-ethyl ascorbic acid

95.5%

10.35µg

2.29 g·g-1

Magnesium ascorbyl phosphate

70.6%

163.44µg

0.15 g ·g-

Ascorbic Acid

<0.01%

8.42µg

2.82g·g-1

 

Fig 1.          Plots of concentration vs. inhibitory activity against tyrosinase-catalyzed oxidation of L-tyrosine.
The inhibitory rate of 3-O-ethyl ascorbic acid on tyrosinase activity in oxidizing L-tyrosine into melanin achieves 80.0%, which is lower than that of kojic acid (inhibitory rate 95.5%), but higher than ascorbic acid (inhibitory rate 68.5%)

 

 

 

Fig. 2         Plots of concentration vs. inhibitory activity against tyrosinase - catalyzed oxidation of L-dopa. Activity of 3-O-ethyl ascorbic acid against capacity of tyrosinase to oxidize L-dopa forming melanin achieves 89.1%. The inhibitor concentration causing 50% loss of activity (IC50 value) is 0.15mmol/L

Documentation:

 

Ethyl ascorbic acid formulation.pdf

msds 3-O-ethyl ascorbic acid.pdf

Copyright © 2017 M.C.Biotec Inc. All Rights Reserved

http://www.mcbiotec.comTel: 0086-139-13923033Fax: 0086-10-80115555 ext 441505

Email: mc@mcbiotec.com; 879845925@qq.com;QQ: 879845925;Skype: mcbiotec2016

Follow Us On Facebook: https://www.facebook.com/mcbiotec