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Alpha-arbutin ( α-arbutin )

CHEMICAL NAME:

4-Hydroxyphenyl-alpha-D-glucopyranoside; Hydroquinone-O-ALPHA-D-glucopyranoside

CAS: 84380-01-8      C12H16O7

Alpha-Arbutin is the more effective, faster and safer approach to skin lightening. It lightens the color of the skin more efficiently and effectively than do existing single components

PROPERTIES:
Alpha-arbutin blocks epidermal melanin biosynthesis by inhibiting enzymatic oxidation of Tyrosine and Dopa. It acts faster and more efficient than do existing single components.

FUCNTION:
*Promotes lightening and an even skin tone on all skin types.
*Minimizes liver spots.
*Can reduce the degree of skin tanning after UV exposure.

COSMETIC APPLICATION:
*All degrees of skin lightening.

FORMULATIONS:
Alpha-arbutin is a water soluble, crystalline, white powder which is easily incorporated into the water phase of cosmetic formulations. Alpha-arbutin is stable against hydrolysis as tested in the pH range from 3.5 to 6.5.

SUGGESTED CONCENTRATION
0.2% when formulated with an exfoliant or penetration enhancer, otherwise up to 2%.

IN-VITRO TEST:
Alpha-arbutin exhibits impressive in-vitro tyrosinase inhibition on human cell lysate (IC50 = 1.0 mMol) as compared to Beta-Arbutin (IC50 = 9.0 mMol).

 

MAIN SPECIFICATIONS:

INCI Name

:

ALPHA-ARBUTIN

CAS No.

:

84380-01-8

EINECS No.

:

283-934-3

Appearance

:

White crystals or crystalline powder

Identification 

:

IR

pH

:

5.0 - 7.0

Melting rang

:

202°C-210°C

Specific rotation[a]20D

:

+175°~+185°

Loss on drying (%)

:

≤1.0

Clarity of water solution

:

Clear, T430nm≥95%

Hydroquinone

:

≤10ppm

Heavy metals

:

≤10ppm

Arsenic

:

≤2 ppm

Ignition residue (%)

:

≤0.5

Assay (%,HPLC)

:

≥99.0

Aerobic Bacterial

:

≤1000 CFU/g

Molds & Yeast Count 

:

≤100 CFU/g

Fecal Coliforms

:

Negative

Pseudomonas Aeruginosa

:

Negative

Staphylococcus Aureus

:

Negative

 

EFFICACY OF ALPHA-ARBUTIN

 

FUNCTION:

• Promotes lightening and an even skin tone on all skin types.

• Minimizes liver spots.

• Can reduce the degree of skin tanning after UV exposure.

 

PROPERTIES:

ALPHA-ARBUTIN blocks epidermal melanin biosynthesis by inhibiting enzymatic oxidation of Tyrosine and Dopa.

 

 

INHIBITION OF TYROSINASE IN VITRO

Alpha-arbutin shows impressive in-vitro tyrosinase inhibition on human cell lysates compared to ß-Arbutin.

 ß-Arbutin: IC50 = 9.0 mMol                       Alpha-arbutin: IC50 = 1.0 mMol

 

SHORT-TERM IN VIVO SKIN-LIGHTENING STUDY

A skin lightening study on 80 Chinese descent women demonstrated that an emulsion containing 1% ALPHA-ARBUTIN results in a faster and more pronounced skin lightening effect after 1 month when compared with other commonly used mono-substances at 1 % each.

Figure 2: The classification of lightening mono-substances according to the magnitude of their specific effect after 1 month.

 

 

IN VIVO LIVER SPOTS EFFICACY STUDY

ALPHA-ARBUTIN (2%) in a cream formulation shows liver spot improving efficacy after 3 months.

 

Figure 3: Satisfaction quotients relating to the evaluation of the liver spot reduction.

 

IN–VIVO TANNING INHIBITING EFFECT AFTER UV EXPOSURE

In a further in–vivo study using 0.5% ALPHA-ARBUTIN in a cream formulation a tanning inhibiting effect after UV exposure has been shown.

Figure 4: Skin tanning prevention after UV exposure.

 

 

 

Documentation:

 

 msds alpha arbutin.pdf

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