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Ciclopirox Olamine

INCI Name

:

Ciclopirox Olamie

Chemical Name /Synonyms

:

Ciclopirox ethanolamine; 6-Cyclohexyl-1-hydroxy-4-methylpyridin-2(1H)-one 2-aminoethanol (1:1)

CAS No.

:

41621-49-2; 29342-05-0 ( free form)

EINECS

:

255-464-9

Molecular Formula

:

C12H17NO2.C2H7NO; C14H24N2O3

Structure                                :

Ciclopirox Olamine structure

 

 

Function

Cosmetic Biocide

Ciclopirox has broad-spectrum action against dermatophytes, yeast, and fungi. Its anti-inflammatory activity has been demonstrated in human polymorphonuclear cells. This agent also inhibits prostaglandin and leukotriene synthesis.  Ciclopirox olamine was effective and safe for mild-to-moderate dandruff.

 

 

General Information:

Description

:

White or pale yellow crystalline powder

Identification

:

IR corresponds to that of reference standard

Loss on drying (%)

:

Not more than 1.5

Residue on ignition (%)

:

Not more than 0.1

Heavy metals (ppm)

:

Not more than 10

Ethanolamine content

:

223~230mg/g

pH

:

8.0-9.0

Related compounds

:

Impurity A<0.5%;

Total Impurities<0.5%;

Any single impurity<0.1%

Assay (%)

:

98.0-101.0

 

 

Use Level

Recommendatory amount of usage: 1-1.5%

 

Documentation:

 

msds ciclopirox olamine.pdf

 

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