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Kojic Dipalmitate

                                                                                                                       

                                                                                                                         Stable alternative to kojic acid

INCI Name : Kojic Dipalmitate
Chemical Name /Synonyms  : 2-palmitoyloxymethyl-5-palmitoyloxy- γ- pyrone;
Hexadecanoic acid, 4-oxo-6-[[(1-oxohexadecyl)oxy]methyl]-4H-pyran-3-yl ester; KAD
Trade Name : MC-KAD
CAS No. : 79725-98-7
Molecular Formula : C38H66O6
Molecular Weight : 618.9
Structure : 

Kojic Dipalmitate

 

BENEFITS

 

Skin lighteningKojic dipalmitate is more efficacious than kojic acid in inhibiting the activity of tyrosinase present in human skin so as to inhibit the melanin formation and produce excellent effects in whitening skin and in anti-suntan.
Solubility and
skin absorbance
Kojic acid dipalmitate is oil soluble and is more easily absorbed into skin when it is incorporated into a cream as compared with kojic acid
Kojic Acid DipalmitateKojic Acid
CompatibilityCompatible with
almost all cosmetic
ingredients, especially
advantageous for use
in combination with
sunscreens
may not be compatible with
some organic sunscreens
and preservatives due to
potential hydrogen bonding
Stability
LightStableUnstable to light
Heat Stable. A cream
containing 1% KAD
found no color change when
kept at 45°C for 4
weeks
Especially unstable above
40°C. A cream containing
1% Kojic acid become deep
yellowish brown when kept at
45°C for 4 weeks
pHStable between 3 and 10Unstable when pH exceed 7
OxidationNot oxidizableParticularly oxidizable
Metal ionsNot complex with
metals
Chelate with metal ions ( e.g.
iron) and color changes occur.
Color
stability
No color change occurEasily become yellow or
brown

 

Functions
 ● Lightening/whitening : Inhibit tyrosinase and melanin formation, ameliorate dermal pigmentation. Provide excellent effects in even toning skin, fighting age spots, pregnancy marks, freckles as well as general pigmentation disorders.
 ● Toning/Invigorating  
 ● Anti-aging

 

Application
Body/facial care toners, anti-aging preparations, sun protection, after-sun & self-tanning, skin whitening/lightening, treatment for a variety of skin hyperpigmentation conditions or disorders, e.g. solar lentigenes, melasma, chloasma, scars, freckles, age pigment and other local hyperpigmented regions of the skin


Use Level:  1 to 5%


Storage 
Store in a cool and dry place. Keep away from direct strong light and heat.

 

Specification
Appearance :   White to almost white crystalline powder.
                           Easily soluble in tetrahydrofuran and hot ethanol
Identification :   IR
Melting point (℃)  :  94.0-97.0
Loss on drying (%) :  ≤ 0.5
Tinctorial reaction of FeCl3 :  Negative
Residue on ignition (%)  : ≤ 0.1
Heavy metals ( pb, ppm) :  <10
Assay (%) :  ≥98.0

 

Formulation Suggestions
KAD is difficult to incorporate into the formulation, and it easily precipitates in the form of crystals. To solve this problem, it is suggested that isopropyl palmitate or isopropyl myristate be added to the oil phase, and heat the oil phase to 80℃ and keep at this temperature for about 5 minutes so that KAD completely dissolved, then add the oil phase to water phase for emulsification at the same temperature for 10 minutes or so. Generally, pH in final product is generally around 5.0—8.0.
Unlike Kojic Acid, which may not be compatible with some organic sunscreens and preservatives due to potential hydrogen bonding, Kojic Dipalmitate is compatible with virtually all ingredients and is especially advantageous for use in combination with sunscreens.

 

Documentation:

 

kojic dipalmitate formulation.pdf

msds kojic dipalmitate.pdf

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